Holoprotein diet as an effective therapeutic supplement in patients with psoriasis.

Psoriasis is a skin disease that consists of the hyperproliferation of epidermal keratinocytes responsible for asymptomatic to itchy lesions that appear as plaques covered with thick, silvery and shiny scales. It is a chronic and relapsing inflammatory pathology with immune-mediated pathogenesis with a strongly negative impact on the quality of life of patients, in which a fundamental role in the physio-pathogenesis is played by visceral adipose tissue, the main source of inflammatory mediators such as TNF -α and IFN-γ. Psoriasis is often associated with various comorbidities, including cardiovascular diseases, metabolic syndrome, obesity, overweight and other problems for which incorrect nutrition can exacerbate the clinical manifestations and favor the development of the disease. Education on modifiable factors such as diet, nutrition, appropriate body weight and physical activity is essential to ensure that these factors do not negatively intervene in the effectiveness of the treatment. the low-calorie ketogenic diet can be considered a successful strategy and a therapeutic option to obtain an improvement in psoriasis-related metabolic dysmetabolism, with significant
correction of the entire metabolic and inflammatory state.
Recent experimental clinical work on psoriatic patients has shown how a nutritional protocol based on a ketogenic diet and a therapy based on natural supplements (Holoprotein Diet) is able to improve clinical symptoms in patients subjected to this dietary regime, with improvement of DLQI (Dermatology Life Quality Index), VAS pruritus scale (Visual Analogue Scale) and PASI (Psoriasis Area Severity Index). The authors also observed a decrease in the concentrations of the main inflammatory cytokines such as IL-2, IL-1β, IFN-γ and IL-4 dosed before and after the ketogenic nutritional regimen and measured the NMR metabolomic profile of the patients' serum identifying specific biomarkers
of psoriasis.
The holoprotein diet can therefore be considered a successful strategy and a therapeutic option to obtain an improvement in psoriasis-related metabolic dysmetabolism, with significant correction of the entire metabolic and inflammatory state.

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