Effectiveness of a ketogenic protocol called the Holoprotein Diet in the treatment of fibromyalgia.

Fibromyalgia, a chronic disease with a high incidence in women, represents a significant challenge in the bio-medical field for both diagnosis and treatment, especially due to the absence of specific biomarkers and the multifaceted nature of its symptoms, which ranging from neuromuscular pain to mood disorders and intestinal dysbiosis. While the diagnosis is currently based on rheumatological clinical assessments and treatment options focus primarily on symptom management, the fibromyalgia patient appears to have possible links to systemic metabolic dysfunctions with a common inflammatory root. In this context, a new therapeutic path emerges: a nutritional approach based on a ketogenic diet and a therapy based on natural supplements (Holoprotein Diet). This is what is presented in a very recent clinical study, which aimed to investigate the specific effects of two dietary interventions, namely the holoprotein diet and the low glycemic insulin diet (LOGI), on two groups of patients. women suffering from fibromyalgia for a period of 45 days. Using clinical and laboratory tests, as well as non-invasive NMR metabolomic analysis of serum, urine and saliva samples, the authors demonstrated how this dietary regimen affects the metabolic dysfunctions associated with fibromyalgia, confirming their decades-long clinical observations on patients with this complex pathology.
Through the lens of metabolomics, finally convincing evidence of the therapeutic potential of the Holoprotein Diet in the management of fibromyalgia symptoms. A new path opens up to more personalized, natural and effective treatment strategies.

Citation
Castaldo, G.,..... & Rastrelli, L. (2024). Investigating the Effectiveness of a Carb-Free Holoprotein Diet in Fibromyalgia Treatment. Nutrients, 16(11), 1620.