Blended Formulations of Proteins and Amino Acids: New Evidence on Their Physiological Benefits for More Targeted Supplementation in Athletes

Adequate supplementation with whey protein isolate is generally considered an optimal nutritional strategy to maximize myofibrillar protein synthesis following strength and endurance exercise, due to its high content of essential amino acids and BCAAs. Additionally, whey proteins have demonstrated various biological properties, including antioxidant, antidiabetic, anti-obesity, and cardioprotective effects.

Recent clinical trials and metabolomic studies conducted on elite athletes from both land and water sports suggest that it may be more beneficial to design formulations that combine whey proteins with specific amino acids—such as ornithine alpha-ketoglutarate, arginine alpha-ketoglutarate, glutamine, citrulline, cysteine, and taurine—as well as creatine, in order to ensure more targeted supplementation and meet the demands of specific sports.

The clinical studies reviewed confirm significant physiological benefits, supporting the claim that blended formulations of proteins and amino acids may have a greater positive impact on endurance and overall athletic performance compared to supplementation with whey protein alone.