STRESSLESS NEW with ashwagandha KSM-66®

Each capsule of Stressless provides a potent mix of two adaptogenic plants, accompanied by optimal dosing to ensure immediate and lasting benefits:

• Ashwagandha KSM66 (Withania somnifera): 600 mg (titrated to 5% withanolides), a traditional adaptogen that increases stress resistance, improves sleep and has neuroprotective effects.
• Bacopa monnieri: 50 mg (titrated to 20% bacosides), known to improve memory, learning and concentration. It has antioxidant and neuroprotective effects that promote long-term brain health.

Other ingredients: vegetable capsules and natural coating agents.

Kiros Stressless is a biologically active supplement that helps:

• Managing stress: reduces cortisol levels and decreases mental and physical tension.
• Improve concentration and mental energy: promotes learning, boosts memory and stimulates creative processes.
• Support mental health: balances mood, reducing anxiety and improving psychological well-being.
• Support memory and cognitive function: thanks to Ashwagandha and Bacopa extracts, improves neuroplasticity and neuronal protection.

Its formulation, with 600 mg of Ashwagandha (titrated to 5 percent withanolides) and 50 mg of Bacopa (titrated to 20 percent bacosides), is designed to ensure effectiveness and maximum absorption. Kiros Stressless acts as a powerful natural adaptogen, helping the body respond better to physical and mental stress, increasing resilience and overall well-being.

• Stress reduction: due to the adaptogenic action of Ashwagandha, it reduces cortisol levels and promotes a balance between body and mind.
• Improved cognitive performance: Bacopa stimulates memory, attention and learning ability.
• Supports mood and psychological well-being: balances mood and improves the body's response in chronic stress situations.
• Increased concentration and mental clarity: helps keep mental energy high even in busy times.
• Support the body's natural defenses: the plants contained also have positive effects on the immune system.

Kiros Stressless is a natural and safe choice for those who want to manage stress, improve cognitive abilities and support mental well-being without resorting to drugs. It is ideal for:

• Those who suffer from daily stress and anxiety.
• Those who wish to improve memory, learning and concentration.
• Those who engage in strenuous physical activity and need support for physical and mental recovery.
• Those seeking natural support to increase mental energy and clarity.

Kiros Stressless is supported by numerous scientific studies confirming the effectiveness of its main ingredients.

Evidence on Ashwagandha 

Ashwagandha is an adaptogenic plant widely studied for its stress-relieving, neuroprotective and cognitive performance-enhancing properties. Scientific research has confirmed that Ashwagandha can significantly contribute to the improvement of physical and mental conditions by acting on various biological mechanisms:

• Stress Reduction and Cortisol Regulation. Numerous studies have shown that Ashwagandha extract can reduce cortisol (the stress hormone) levels in the blood. In a clinical trial conducted on individuals with chronic stress, administration of Ashwagandha led to a significant reduction in cortisol and an overall improvement in mental and physical well-being. This effect makes it a powerful adaptogen that helps the body manage physical and mental stress more efficiently (1,2).
• Benefits on Cognitive Function. Ashwagandha has also demonstrated an enhancing effect on memory and cognitive abilities. In a study of patients with mild cognitive impairment (MCI), participants who took ashwagandha reported improvements in cognitive scores and memory abilities. Its activity is related to protecting neurons from oxidative damage, which is a key factor in age-related cognitive decline (3,4).
• Neuroprotection and Prevention of Neurodegenerative Diseases.Ashwagandha has also been studied for its protective effects against neurodegenerative diseases, such as Alzheimer's and Parkinson's. Studies suggest that withanolides in the plant act as potent antioxidants and neuroprotectors, protecting neurons from oxidative damage and cellular changes typical of these diseases (5,6).

Evidence on Bacopa (Bacopa monnieri).

Bacopa monnieri, another adaptogenic plant traditionally used to improve cognitive abilities and reduce stress, has been the subject of numerous scientific studies confirming its positive effects on mental health and the nervous system:

• Cognitive Enhancement and Memory. Bacopa is widely known for its nootropic effect, that is, its ability to improve cognitive function, particularly memory and concentration. Clinical studies have confirmed that taking Bacopa improves reaction time and short-term memory. In a study of elderly people, Bacopa was shown to slow cognitive decline and improve verbal memory (7,8).
• Antioxidant and Neuroprotective Action. Bacosides, the main bioactive compounds in Bacopa, possess potent antioxidant properties that protect neurons from oxidative damage. Several studies have confirmed that Bacopa reduces oxidative stress and promotes neuroplasticity by increasing synaptogenesis and improving communication between neurons (Bacopa could be useful in counteracting age-related cognitive decline and preventing neurodegenerative diseases (9,10).
• Mood and Anxiety Modulation. Bacopa also has positive effects on mood. Clinical studies have shown that Bacopa can reduce anxiety levels and improve psychological well-being. This effect is related to its ability to modulate neurotransmitters such as serotonin and GABA, which regulate mood and stress response (11,12).
  

Study on ST-65 (Ashwagandha-Bacopa Formulation)
A recent study investigated the combined formulation of Ashwagandha (600 mg) and Bacopa (50 mg), called ST-65 (the basis of Kiros Stressless), using an advanced metabolomics approach to explore the cellular and molecular effects of the synergy between these two potent adaptogens (13). The results are promising and show how this combination can improve both stress management and cognitive and neuroprotective functions:

• Neuroprotective Effects and Oxidative Stress Reduction. Treatment with Stres slessha led to a significant increase in neuroprotective metabolites in SH-SY5Y neuroblastoma cells. This suggests that the combination of ashwagandha and bacopa activates cellular mechanisms that protect neurons from oxidative damage caused by stress by enhancing antioxidant defenses and energy metabolism. Increased glutamate and modulation of the citric acid cycle (TCA) are indicators of improved mitochondrial bioenergetics, a crucial process for brain health and protection against neurodegenerative diseases.
• Improved Mitochondrial Function and Neural Protection. ST-65 has been shown to increase levels of Coenzyme A (CoA), a key factor in cellular energy production. Improving mitochondrial function is particularly relevant to neurodegenerative diseases, such as Alzheimer's and Parkinson's, which are often characterized by mitochondrial dysfunction. In addition, metabolomic analysis has shown improved lipid metabolism, which is beneficial for myelination processes and oligodendrocyte function, which are essential for neuronal communication.
• Neurosteroid Modulation and Neurogenesis. The study also identified an upregulation of steroid biosynthesis pathways, including androgen and estrogen metabolites, which are crucial for neurosteroid modulation. These hormones not only mitigate oxidative stress, but also promote neurogenesis and synaptic plasticity, promoting neuronal resilience and improved cognitive abilities. In particular, neurosteroids play an important role in synaptogenesis, protection against inflammation, and support of immunomodulation.
• Improved Metabolic and Cognitive Pathways. The ST-65 formulation also modulated amino acid pathways, with increased glutamate and decreased use of aspartate and tryptophan, suggesting an improvement in the effectiveness of neuronal communications and neuronal resilience. In addition, it was observed that the combination of these two adaptogens modulates the MAPK and PI3K/Akt pathways, which are known to play a protective role against oxidative stress, inflammation, and neuronal death.

Conclusions of the Study
The study on ST-65 (Kiros Stressless) confirms that the combination of Ashwagandha and Bacopa has synergistic effects that enhance stress management, cognitive enhancement, and neuroprotection. Through its adaptogenic and neuroprotective effects, ST-65 is proposed as an effective natural solution to manage stress, improve cognitive function, and protect the nervous system from oxidation-induced damage and neurological decline.

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2. Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628.
3. Kuboyama, T., Tohda, C., & Komatsu, K. (2005). Neuritic regeneration and synaptic reconstruction induced by withanolide A. British journal of pharmacology, 144(7), 961-971.
4. Kulkarni, S. K., & Dhir, A. (2008). Withania somnifera: an Indian ginseng. Progress in neuro-psychopharmacology and biological psychiatry, 32(5), 1093-1105.
5. Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine, 20(12), 901-908.
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7. Preethi, J., Singh, H. K., Charles, P. D., & Rajan, K. E. (2012). Participation of microRNA 124-CREB pathway: a parallel memory enhancing mechanism of standardized extract of Bacopa monniera (BESEB CDRI-08). Neurochemical research, 37(10), 2167-2177.
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9. Malishev, R., Shaham-Niv, S., Nandi, S., Kolusheva, S., Gazit, E., & Jelinek, R. (2017). Bacoside-A, an Indian Traditional-Medicine Substance, Inhibits β-Amyloid Cytotoxicity, Fibrillation, and Membrane Interactions. ACS chemical neuroscience, 8(4), 884-891.Agarwal, S., Chaudhary, B., & Bist, R. (2017). Protective propensity of bacoside A and bromelain on renal cholinesterases, γ-aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos. Chemico-biological interactions, 261, 139-144.
10. Russo, A., Borrelli, F., Campisi, A., Acquaviva, R., Raciti, G., & Vanella, A. (2003). Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera. Life sciences, 73(12), 1517-1526.
11. Limpeanchob, N., Jaipan, S., Rattanakaruna, S., Phrompittayarat, W., & Ingkaninan, K. (2008). Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. Journal of ethnopharmacology, 120(1), 112-117.
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13. D'Elia, M., Marino, C., Celano, R., Napolitano, E., D'Ursi, A. M., Russo, M., & Rastrelli, L. (2024). Impact of a Withania somnifera and Bacopa monnieri Formulation on SH-SY5Y Human Neuroblastoma Cells Metabolism Through NMR Metabolomic. Nutrients, 16(23), 4096.