LIPOVIT

Each capsule of Kiros Lipovit contains a combination of fat-soluble vitamins:

• Vitamin D3: 2000 IU (50 μg ) (active form that supports calcium absorption and immune system health).
• Vitamin K2: 100 mcg (contributes to blood clotting and bone health).
• Vitamin A: 400 mcg (retinol and carotenoids, critical for vision and skin health).

Additional ingredients: Vegetable capsules.

Kiros Lipovit is a balanced formulation that combines three fat-soluble vitamins critical for different physiological functions. Here's how each vitamin contributes to health:

• Vitamin D3 - Immune and Bone Wellness Vitamin D3 is crucial for the immune system, improving the body's response to infection. Promotes calcium and phosphorus absorption, supporting bone mineralization. It helps maintain strong bones and prevent diseases such as osteoporosis. 
• Vitamin K2 - Bone and cardiovascular health: Vitamin K2 is essential for proper calcium metabolism, promoting calcium accumulation in bones and preventing calcification of arteries and soft tissues. Its supplementation helps maintain strong bones and prevent cardiovascular disease related to vascular calcification.
• Vitamin A - Skin and Vision Health: Vitamin A plays a crucial role in supporting vision (particularly night vision) and cell growth. In addition, it is essential for the immune system and red blood cell production. Its antioxidant action protects cells from aging and free radical damage, and it promotes healthy skin, hair, and mucous membranes.

The main benefits of Kiros Lipovit include:

• Improved bone health: The combination of vitamin D3 and vitamin K2 supports bone mineralization, preventing osteoporosis and improving bone density.
• Immune system support: Vitamin D3 helps strengthen the body's natural defenses, while vitamin A supports immune function.
• Cellular protection: Vitamin A has antioxidant effects, protecting cells from oxidative stress and preventing tissue damage.
• Cardiovascular health: Vitamin K2 is crucial in preventing calcification of blood vessels, reducing the risks of cardiovascular disease.

Kiros Lipovit provides vitamin D3 (50 μg), the biologically active form of vitamin D, which plays a key role in optimizing immune system function and protecting against chronic diseases, including cancer. Supplementation with vitamin D may be particularly useful for those who are deficient in this vitamin, to ensure adequate levels and gain all the benefits related to its ability to modulate inflammation and protect the body from disease. 

Kiros Lipovit is also formulated to offer a potent combination of fat-soluble vitamins in an optimal dosage for overall health. Due to its balanced formulation, it supports:

• Bones: Due to the combination of vitamin D3 and vitamin K2, which promotes mineralization and prevents osteoporosis.
• Immune system: L vitamin D3 and vitamin A are essential for a healthy and responsive immune system.
• Cellular well-being: With vitamin A, which has antioxidant action, Kiros Lipovit protects cells from oxidative damage.
• Easy absorption: Fat-soluble vitamins are better absorbed when taken with meals, providing greater efficacy.

Evidence on Vitamin D

 Vitamin D is crucial for bone health by promoting the absorption of calcium and phosphorus in the gut. Its deficiency has been associated with an increased risk of osteoporosis, muscle pain, and immune system disorders. In addition, recent studies have shown that vitamin D can improve the treatment of fibromyalgia by reducing symptoms of musculoskeletal pain and fatigue. Vitamin D is not only critical for bone health and calcium regulation, but also plays a central role in strengthening the immune system and preventing many chronic disorders, including cancer. Many scientific studies have shown that adequate levels of vitamin D can reduce the risk of developing several types of cancer and positively affect the course of some cancer diseases (1-6).

• Immune System and Defense Against Infection. Vitamin D acts as a modulator of the immune system, enhancing the response to infection and protecting against autoimmune diseases. It promotes the production of antimicrobial peptides and stimulates the response of T cells and dendritic cells, which are essential for defense against pathogens. In particular, vitamin D helps regulate immune cell activity, reducing inflammation and preventing excessive immune reactions that can lead to autoimmune diseases.
• Cancer Prevention Epidemiological and clinical studies have suggested that adequate vitamin D levels may help reduce the risk of developing various types of cancer, including colon, breast, prostate, and lung cancer. Vitamin D appears to be able to regulate cell growth and inflammation, processes that are frequently altered in cancer cells.
• Molecular Mechanisms: Vitamin D acts by binding to its receptor (VDR) in cells, affecting the expression of genes involved in cell proliferation, differentiation, and apoptosis. This process can limit tumor growth and prevent metastasis formation.

Evidence on Vitamin K2

Vitamin K2 plays a key role in bone health and calcium metabolism. Its ability to activate proteins such as osteocalcin and Matrix GLA Protein helps prevent calcification of blood vessels and promote calcium accumulation in bones, reducing the risks of osteoporosis and cardiovascular disease.

Vitamin A is crucial for immune function, vision, and protection of cells from oxidative stress. Studies have shown that adequate vitamin A intake can reduce the risk of infection and improve visual function (7-10).

Evidence on Vitamin A

Vitamin A is crucial for immune function, vision, and protection of cells from oxidative stress. Studies have shown that adequate vitamin A intake can reduce the risk of infection and improve visual function (11-15).

1. Cranney, A., Horsley, T., O'Donnell, S., Weiler, H., Puil, L., Ooi, D., ... & Fang, M. (2007). Effectiveness and safety of vitamin D in relation to bone health. Evidence report/technology assessment, (158),
2. Khan, Q. J., Reddy, P. S., Kimler, B. F., Sharma, P., Baxa, S. E., O'Dea, A. P., ... & Fabian, C. J. (2010). Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer. Breast cancer research and treatment, 119(1), 111. 
3. Solmaz, D., Avci, O., Yalcin, B. C., Kara, S. P., & Oran, M. (2015). AB0944 Vitamin D Deficiency Might Contribute Fatigue and Disease Activity in Patients with Fibromyalgia.
4. Armstrong, D. J., Meenagh, G. K., Bickle, I., Lee, A. S. H., Curran, E. S., & Finch, M. B. (2007). Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clinical rheumatology, 26(4), 551-554. 
5. Lim, Y. Y., Kim, S. Y., Kim, H. M., Li, K. S., Kim, M. N., Park, K. C., & Kim, B. J. (2014). Potential relationship between the canonical W nt signaling pathway and expression of the vitamin D receptor in alopecia. Clinical and experimental dermatology, 39(3), 368-375.
6. Rasheed, H., Mahgoub, D., Hegazy, R., El-Komy, M., Hay, R. A., Hamid, M. A., & Hamdy, E. (2013). Serum ferritin and vitamin D in female hair loss: do they play a role?. Skin pharmacology and physiology, 26(2), 101-107.
7. Booth SL. Vitamin K: food composition and dietary intakes. Food Nutr Res 2012;56.
8. Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001.
9. Elder SJ, Haytowitz DB, Howe J, Peterson JW, Booth SL. Vitamin K contents of meat, dairy, and fast foods in the U.S. Diet. J Agric Food Chem 2006;54:463-7. 
10. Suttie JW. Vitamin K. In: Coates PM, Betz JM, Blackman MR, et al, eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:851-60.
11. Johnson EJ, Russell RM. Beta-Carotene. In: Coates PM, Betz JM, Blackman MR, et al, eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:115-20.
12. Ross CA. Vitamin A. In: Coates PM, Betz JM, Blackman MR, et al, eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:778-91.
13. Ross A. Vitamin A and Carotenoids. In: Shils M, Shike M, Ross A, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2006:351-75.
14. Zhong, M., Kawaguchi, R., Kassai, M., & Sun, H. (2012). Retina, retinol, retinal and the natural history of vitamin A as a light sensor. Nutrients, 4(12), 2069-2096.
15. St. John, J. P., Chew, E. Y., Clemons, T. E., Ferris 3rd, F. L., Gensler, G., Lindblad, A. S., ... & Sperduto, R. D. (2007). The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study. Arch Ophthalmol, 125(9), 1225-1232.