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DE:STRESS with ashwagandha KSM-66®

Effective Ayurvedic and Chinese mycotherapy phytotherapeutics to combat stress and improve optimism

DE:STRESS is a dietary supplement containing Withania somnifera (Ashwagandha), Cordyceps sinensis, and Vitamin C, designed to improve concentration, reduce stress, and increase mental and physical energy. A unique combination of ingredients with strong nootropic, immune-stimulating, and anti-stress properties that act synergistically to improve mental and physical well-being.

Format: 60 vegetarian capsules per package.

Dosage: Take 1 capsule before breakfast and 1 capsule before dinner, or as directed by your doctor or nutritionist.

Buy DE:STRESS now to experience the benefits of a natural and effective supplement that will help you manage stress, regain your inner harmony, optimism and mental clarity.

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€22,00
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Composition

Each dose (2 capsules per day) provides:

  • 600 mg Ashwagandha KSM66 (extract standardized to 5 percent withanolides)
  • 100 mg of Cordyceps sinensis (extract standardized to 40 percent polysaccharides)
  • 60 mg of Vitamin C
Properties and Efficacy

Each capsule of DE:STRESS provides a potent mix of two adaptogenic plants, accompanied by optimal dosing to ensure immediate and lasting benefits:

Ashwagandha (Withania somnifera) is a powerful adaptogen that helps reduce stress, improve concentration and promote mental relaxation. It helps maintain balanced levels of serotonin and dopamine, key hormones for mood and psychological well-being.

Cordyceps sinensis is a Chinese mushroom that increases energy, concentration, and cognitive performance. It stimulates memory and learning ability, while also supporting the immune system and fighting oxidative stress.

Vitamin C plays a protective role against cellular damage and supports the immune system, counteracting cellular aging.

The combination of these ingredients promotes significant improvement in mental clarity, creativity and concentration, reducing symptoms of stress and anxiety.

Main Benefits
  • Stress reduction: Promotes a balance between body and mind by lowering cortisol (the stress hormone) levels.
  • Improved concentration: Increases mental clarity and promotes memory.
  • Immune system support: Vitamin C and Cordyceps strengthen the body's natural defenses.
  • Mood balance: Helps combat anxiety, depression and mental restlessness.
  • Increased energy: Stimulates physical and mental endurance, improving cognitive performance.
Why Choose?

Cordyceps sinensis and Ashwagandha (Withania somnifera) are two of the most studied herbs in traditional medicine for their beneficial properties on the body and mind.  The synergistic action of Cordyceps, Ashwagandha and Vitamin C creates a powerful complex that can support the body in many ways. Cordyceps boosts energy and physical endurance, improving oxygenation and circulation, while Ashwagandha acts as an adaptogen, reducing stress and promoting mental and hormonal balance. Vitamin C strengthens the immune system and combats oxidative stress. Together, these three ingredients work in complementary ways, improving physical performance, supporting mental health, and protecting the body from damage caused by stress and aging. Their combination, as in Kiros DE:STRESS, is especially helpful in supporting energy, concentration, and emotional balance.

Scientific Studies and Insights

Cordyceps Sinensis: from Chinese mycology a natural stimulant and performance enhancer

Cordyceps sinensis is a medicinal mushroom known for its powerful adaptogenic and energizing properties. It is traditionally used to improve physical and mental performance due to its ability to increase the production of ATP (adenosine triphosphate), the main source of energy for the body's cells. This mushroom improves cell oxygenation, supporting endurance during physical activity and reducing fatigue. In addition, Cordyceps has a positive effect on blood circulation due to its cardiotonic properties, promoting more efficient blood flow. Its active ingredients, such as cordiceps, are also known to have antioxidant and ergogenic properties, making it useful for counteracting oxidative stress and improving brain function, with positive effects on memory and learning. Scientific studies have shown that Cordyceps' active components, such as chordiceps (an adenine derivative) and chordicepic acid, have ergogenic, antiproliferative, pro-apoptotic (promoting programmed cell death of abnormal cells), and anti-inflammatory properties. These effects make it a powerful ally for protection against oxidative stress and for improving memory and cognitive function. Cordiceps has been shown to act as an inhibitor of acetylcholinesterase (AChEI), a mechanism that helps improve memory and learning, and is also used in the treatment of neurodegenerative diseases such as Alzheimer's. In other studies, Cordyceps reduces lipid peroxidation (damage caused by free radicals) in the brain, improving cognitive function, memory, and concentration (1-10).

Ashwagandha: the powerful adaptogen in Ayurvedic medicine

Ashwagandha (Withania somnifera) is one of the most widely studied and used adaptogens in Ayurvedic medicine. Known for its tonic, stress-relieving and neuroprotective properties, it is traditionally used to increase physical and mental endurance, improve sleep quality and support hormonal balance. Withanolides, the main active compounds in Ashwagandha, are responsible for many of its therapeutic properties, including reducing the stress hormone cortisol. This effect makes Ashwagandha useful for those facing periods of anxiety, fatigue, or chronic stress. In addition, Ashwagandha extract has shown potential in countering neurodegenerative disorders, such as Alzheimer's and Parkinson's, due to its neuroprotective properties and ability to stimulate neuronal regeneration. It is also known to improve cognitive function, memory, and concentration, promoting optimal mental and physical balance.

Scientific studies have shown that Ashwagandha can protect the brain from oxidative stress that leads to degeneration of brain cells. In experimental modes, Ashwagandha extract improved memory and cognitive abilities, and increased resistance to physical and mental stress, especially during periods of intense fatigue or illness. In addition, Ashwagandha has a natural sedative effect, similar to GABA (a neurotransmitter that reduces neural excitability), which promotes sleep and mental serenity. In models of neurodegeneration (such as Parkinson's disease and Alzheimer's), Ashwagandha has shown the ability to stimulate neuronal regeneration, promoting dendrite formation and protection from brain injury (11-18).

Vitamin C: Powerful Antioxidant and Immune Support

Vitamin C, or ascorbic acid, is an essential nutrient for the human body, known for its powerful antioxidant properties and key role in supporting the immune system. Vitamin C protects cells from damage caused by free radicals, reducing oxidative stress and preventing premature aging. It is also crucial for the synthesis of collagen, a protein that supports healthy skin, bones, blood vessels, and muscles. In addition, vitamin C is critical for the proper functioning of the immune system, helping to prevent infection and strengthen the body's natural defenses. In combination with Cordyceps and Ashwagandha, vitamin C amplifies antioxidant effects and strengthens the immune system, creating a powerful synergy to support physical and mental health, improve energy, and counteract the effects of stress (19-20).

Literature
  1. HAN, Y. B., ZHAO, P., LI, B., ZHANG, J. H., FU, W. Z., YANG, J. F., ... & HUANG, C. P. (2009). Experimental study of cordycepin tablets on alleviating physical fatigue function of animal [J]. Chinese Journal of Health Laboratory Technology, 11, 015. 
  2. Mushrooms, M. (1995). An Exploration of Tradition, Healing and Culture. Christopher Hobbs.
  3. Wong, Y. Y., Moon, A., Duffin, R., Barthet-Barateig, A., Meijer, H. A., Clemens, M. J., & de Moor, C. H. (2010). Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. Journal of Biological Chemistry, 285(4), 2610-2621.
  4. Gong, M. F., Xu, J. P., Chu, Z. Y., & Luan, J. (2011). Effect of Cordyceps sinensis sporocarp on learning-memory in mice.  Journal of Chinese medicinal materials, 34(9), 1403-1405. 
  5. Zhou, X., Luo, L., Dressel, W., Shadier, G., Krumbiegel, D., Schmidtke, P., ... & Meyer, C. U. (2008). Cordycepin is an immunoregulatory active ingredient of Cordycepssinensis. The American Journal of Chinese Medicine, 36(05), 967-980.
  6. Kuo, Y. C., Tsai, W. J., Shiao, M. S., Chen, C. F., & Lin, C. Y. (1996). Cordycepssinensis as an immunomodulatory agent. The American journal of Chinese medicine, 24(02), 111-125.
  7. Xiao, Y., Huang, X. Z., Chen, G., Wang, M. B., Zhu, J. S., & Cooper, C. B. (1999). Increased aerobic capacity in healthy elderly humans given a fermentation product of cordyceps Cs-4. Medicine & Science in Sports &Exercise, 31(5), S174.
  8. Kumar, R., Negi, P. S., Singh, B., Ilavazhagan, G., Bhargava, K., &Sethy, N. K. (2011). Cordycepssinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. Journal of ethnopharmacology, 136(1), 260-266.
  9. Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4® (Cordycepssinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. The Journal of Alternative and Complementary Medicine, 16(5), 585-590.
  10. Ji, D. B., Ye, J., Li, C. L., Wang, Y. H., Zhao, J., & Cai, S. Q. (2009). Antiaging effect of Cordyceps sinensis extract. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(1), 116-122.
  11. Kuboyama, T., Tohda, C., & Komatsu, K. (2005). Neuritic regeneration and synaptic reconstruction induced by withanolide A. British journal of pharmacology, 144(7), 961-971.
  12. Kulkarni, S. K., & Dhir, A. (2008). Withania somnifera: an Indian ginseng. Progress in neuro-psychopharmacology and biological psychiatry, 32(5), 1093-1105.
  13. Semwal, P., Kapoor, T., Anthwal, P., Sati, B., & Thapliyal, A. (2014). Herbal extract as potential modulator and drug for synaptic plasticity and neurodegenerative disorders. Int J Pham Sci Rev Res, 25, 69-79.
  14. Wadhwa, R., Konar, A., & Kaul, S. C. (2016). Nootropic potential of ashwagandha leaves: Beyond traditional root extracts. Neurochemistry international, 95, 109-118.
  15. Misra, D., Maiti, B., & Ghosh, D. (2009). Protection of swimming-induced oxidative stress in some vital organs by the treatment of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinalis in male rat. African Journal of Traditional, Complementary and Alternative Medicines, 6(4).
  16. Baitharu, I., Jain, V., Deep, S. N., Shroff, S., Sahu, J. K., Naik, P. K., & Ilavazhagan, G. (2014). Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PloS one, 9(10), e105311.
  17. Grover, A., Shandilya, A., Agrawal, V., Bisaria, V. S., & Sundar, D. (2012). Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer's treatment. Journal of Biomolecular Structure and Dynamics, 29(4), 651-662.
  18. Jansen, R. L. M., Brogan, B., Whitworth, A. J., & Okello, E. J. (2014). Effects of five Ayurvedic herbs on locomotor behavior in a Drosophila melanogaster Parkinson's disease model. Phytotherapy research, 28(12), 1789-1795.
  19. Rogers, D. R., Lawlor, D. J., & Moeller, J. L. (2023). Vitamin C Supplementation and Athletic Performance: A Review. Current sports medicine reports, 22(7), 255-259.
  20. Moore, A., & Khanna, D. (2023). The role of vitamin C in human immunity and its treatment potential against COVID-19: a review article. Cureus, 15(1).

About Us

Kiros Diet

We offer high quality natural food supplements and phytoterapics products based on 25 years of research and clinical studies.

Our supplements: with the right vitamins, natural substances and herbal extracts, we can now optimize mental and physical energy, support immune system, improve quality of life in the long term, and so much more. The supplements developed by our team offer the highest level of safety and efficiency.

How Kiros Diet supplements come about
From the collaboration between Prof. Giuseppe Castaldo and Prof. Luca Rastrelli of the Department of Pharmacy at the University of Salerno, an internationally renowned center of excellence in the field of nutritional supplements and nutraceuticals research.

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