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COLONDRAIN

Ayurvedic phytotherapeutics with intestinal draining activity to prevent and combat constipation

Kiros Colondrain is a dietary supplement designed for those seeking a natural remedy to improve intestinal health, support digestion and promote body purification. By combining Triphala and Artichoke, two ingredients validated by science and tradition, Kiros Colondrain is a complete solution for those who want to take care of their well-being naturally.

Format: 60 natural tablets
Dosage: Take 1-2 tablets before bedtime or as directed by your doctor or nutritionist.
Buy now: Regain wellness and intestinal balance with Kiros Colondrain!

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€19,00
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Composition

Each Kiros Colondrain tablet contains:

  • Triphala (750 mg) - Extracts of Phyllanthus emblica (250 mg), Terminalia chebula (250 mg) and Terminalia bellerica (250 mg), a powerful Ayurvedic combination for intestinal cleansing and body purification.
  • Artichoke Extract (150 mg) - titrated to 5 % chlorogenic acid. Aids in liver purification by promoting bile production and supporting digestive health.

Additional ingredients: Anti-caking agents (magnesium stearate, microcrystalline cellulose).

Properties and Efficacy

Kiros Colondrain is a unique dietary supplement that harnesses Ayurvedic tradition to support digestive health and promote body purification. Its combined formula, based on Triphala (an Ayurvedic remedy composed of Amalaki, Bibhitaki and Haritaki) and Artichoke extract, acts synergistically to improve intestinal motility, stimulate digestion, promote toxin elimination and support liver health.

Triphala extract is particularly known for its cleansing and purifying abilities, while Artichoke, rich in phenolic acids and inulin, supports liver function and lowers cholesterol levels.

Synergy. The combined action of Triphala and Artichoke in Kiros Colondrain offers a synergistic approach that promotes intestinal health, aids digestion, and supports liver function. Triphala stimulates intestinal motility and balances intestinal flora, while Artichoke improves fat digestion and supports lipid metabolism, reducing cholesterol.This synergy makes Kiros Colondrain a useful supplement to improve digestion, prevent constipation, promote hepatic detoxification, and promote a healthy lipid profile.

Main Benefits

Kiros Colondrain is your ideal ally for:

  • Support gut health: Helps reduce constipation, abdominal bloating and flatulence.
  • Improve digestion: Stimulates bile production and promotes intestinal motility.
  • Detoxify the body: Promotes toxin elimination and cell renewal.
  • Support the liver: Artichoke extract promotes liver purification, improving digestion.
  • Regulate cholesterol: Regulates cholesterol and triglyceride levels in the blood.
Why Choose?
  • Natural Synergy: The combination of Triphala and Artichoke is a powerful digestive health remedy that acts synergistically to optimize intestinal well-being.
  • Tradition and science: Backed by centuries of use in Ayurvedic medicine and validated by scientific studies, this supplement is a natural and safe solution for your well-being.
  • Comprehensive Remedy: Not only a digestive support, but also a depurative and antioxidant, Kiros Colondrain helps rebalance the body all-around.
Scientific Studies and Insights
  • Triphala (composed of Emblica officinalis, Terminalia chebula, and Terminalia bellerica) is a traditional remedy in Ayurvedic medicine with extensive scientific evidence supporting its efficacy in various areas, particularly on intestinal and liver health (1-18).
  • Gastroprotective Action and Intestinal Motility. Studies have shown that Triphala stimulates intestinal motility, improving constipation and reducing meteorism. It also acts as a physiological laxative, promoting evacuation and intestinal transit 
  • Antioxidant Properties. Triphala is rich in flavonoids and phenolic acids that impart powerful antioxidant effects, protecting the intestinal mucosa from oxidative stress and improving gastrointestinal health 
  • Prebiotic Effects. Triphala supports the intestinal microbiota by promoting the growth of beneficial bacteria such as Lactobacillus and Bifidobacterium, improving the balance of intestinal flora 
  • Artichoke: Hepatoprotective and Lipid Benefits.
    Artichoke is known for its hepatoprotective and choleretic properties, due to the presence of caffeoylquinic acids and flavonoids, making it useful for liver health and lipid regulation (19-25).
  • Hepatoprotective and Choleretic Effect. Artichoke extracts protect the liver from oxidative damage and stimulate bile production, improving fat digestion and supporting liver function 
  • Lipid Regulation. Artichoke has hypolipidemic effects, reducing LDL cholesterol and increasing HDL cholesterol, thus improving lipid profile and preventing dyslipidemia 
  • Prebiotic Properties. Due to its high inulin content, artichoke promotes a prebiotic action, encouraging the growth of beneficial intestinal bacteria and contributing to a better balance of the intestinal microbiota
Literature
  1. Zunder, T., Huber, R., Sander, A., Daschner, F., & Frank, U. (2002). The pathogenetic significance of intestinal Candida colonization-a systematic review from an interdisciplinary and environmental medical point of view. International journal of hygiene and environmental health, 205(4), 257-268.
  2. Olennikov, D., Kashchenko, N., & Chirikova, N. (2015). In vitro bio accessibility, human gut microbiota metabolites and hepato protective potential of chebulic ellagitannins: A case of Padma Hepaten® formulation. Nutrients, 7(10), 8456-8477
  3. Lu, K., Chakroborty, D., Sarkar, C., Lu, T., Xie, Z., Liu, Z., & Basu, S. (2012). Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One, 7(8), e43934.
  4. Belapurkar, P., Goyal, P., & Tiwari-Barua, P. (2014). Immunomodulatory effects of Triphala and its individual constituents: a review. Indian journal of pharmaceutical sciences, 76(6), 467.
  5. Lee, H. S., Won, N. H., Kim, K. H., Lee, H., Jun, W., & Lee, K. W. (2005). Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biological and Pharmaceutical Bulletin, 28(9), 1639-1644.
  6. iradar, Y. S., Singh, R., Sharma, K., Dhalwal, K., Bodhankar, S. L., & Khandelwal, K. R. (2008). Evaluation of anti-diarrhoeal property and acute toxicity of Triphala Mashi, an Ayurvedic formulation. Journal of herbal pharmacotherapy, 7 (3-4), 203-212.
  7. Nariya, M., Shukla, V., Jain, S., & Ravishankar, B. (2009). Comparison of enteroprotective efficacy of Triphala formulations (Indian Herba lDrug) on methotrexate-induced small intestinal damage in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(8), 1092-1098.
  8. Nariya, M. B., Shukla, V. J., Ravishankar, B., & ain, S. M. (2011). Comparison of gastroprotective effects of Triphala formulations on stress-induced ulcer in rats. Indian journal of pharmaceutical sciences, 73(6), 682.
  9. Mukherjee, P. K., Rai, S., Bhattacharyya, S., Kumar Debnath, P., Biswas, T. K., Jana, U., ... & Paul, P. K. (2006). Clinical study of Triphala. A well known phytomedicine from India. Iranian journal of pharmacology and therapeutics, 5(1), 51-0.
  10. Rayudu, V., &Raju, A. B. (2014). Effect of Triphala on dextran sulphate sodium-induced colitis in rats. Ayu, 35(3), 333.
  11. Gurjar, S., Pal, A., & Kapur, S. (2012). Triphala and Its Constituents Ameliorate Visceral Adiposity From a High-fat Diet in Mice With Diet-induced Obesity. Alternative Therapies in Health & Medicine, 18(6).
  12. Kamali, S. H., Khalaj, A. R., Hasani-Ranjbar, S., Esfehani, M. M., Kamalinejad, M., Soheil, O., &Kamali, S. A. (2012). Efficacy of 'Itrifal Saghir', a combination of three medicinal plants in the treatment of obesity; A randomized controlled trial. DARU Journal of Pharmaceutical Sciences, 20(1), 33.
  13. Rajan, S. S., & Antony, S. (2008). Hypoglycemic effect of Triphala on selected noninsulin dependent diabetes mellitus subjects. Ancient science of life, 27(3), 45.
  14. Yang, M. H., Vasquez, Y., Ali, Z., Khan, I. A., & Khan, S. I. (2013). Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiation. Journal of Ethnopharmacology, 149(2), 490-498.
  15. Baliga, M. S. (2010). Triphala, Ayurvedic formulation for treating and preventing cancer: a review. The Journal of Alternative and Complementary Medicine, 16(12), 1301-1308.
  16. Saravanan, S., Srikumar, R., Manikandan, S., Parthasarathy, N. J., & Devi, R. S. (2007). Hypolipidemic effect of triphala in experimentally induced hypercholesteremic rats. Yakugaku Zasshi, 127(2), 385-388.
  17. Kalaiselvan, S., & Rasool, M. (2015). Triphala exhibits anti-arthritic effect by ameliorating bone and cartilage degradation in adjuvant-induced arthritic rats. Immunological investigations, 44(4), 411-426.
  18. Munshi, R., Bhalerao, S., Rathi, P., Kuber, V. V., Nipanikar, S. U., & Kadbhane, K. P. (2011). An open-label, prospective clinical study to evaluate the efficacy and safety of TLPL/AY/01/2008 in the management of functional constipation. Journal of Ayurveda and integrative medicine, 2(3), 144.
  19. Rajan, S. S., & Antony, S. (2008). Hypoglycemic effect of triphala on selected noninsulin dependent diabetes mellitus subjects. Ancient science of life, 27(3), 45.
  20. Panahi, Y., Kianpour, P., Mohtashami, R., Atkin, S. L., Butler, A. E., Jafari, R., ... &Sahebkar, A. (2018). Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytotherapy research, 32(7), 1382-1387.
  21. Pagano, I., Piccinelli, A. L., Celano, R., Campone, L., Gazzerro, P., De Falco, E., & Rastrelli, L. (2016). Chemical profile and cellular antioxidant activity of artichoke by-products. Food&function, 7(12), 4841-4850.
  22. Miccadei, S., Di Venere, D., Cardinali, A., Romano, F., Durazzo, A., Foddai, M. S., ... & Maiani, G. (2008). Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutrition and cancer, 60(2), 276-283.
  23. Gebhardt, R., &Fausel, M. (1997). Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Toxicology in vitro, 11(5), 669-672.
  24. Pérez-García, F., Adzet, T., & Cañigueral, S. (2000). Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radical Research, 33(5), 661-665.

About Us

Kiros Diet

We offer high quality natural food supplements and phytoterapics products based on 25 years of research and clinical studies.

Our supplements: with the right vitamins, natural substances and herbal extracts, we can now optimize mental and physical energy, support immune system, improve quality of life in the long term, and so much more. The supplements developed by our team offer the highest level of safety and efficiency.

How Kiros Diet supplements come about
From the collaboration between Prof. Giuseppe Castaldo and Prof. Luca Rastrelli of the Department of Pharmacy at the University of Salerno, an internationally renowned center of excellence in the field of nutritional supplements and nutraceuticals research.

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